Biolayer Interferometry Applications

BLI technology revolutionizes protein quantitation with its ability to provide fast, accurate, and label-free measurements. Researchers can precisely determine protein concentrations, even in complex or unpurified samples, without the need for extensive sample preparation. This streamlined process saves valuable time and ensures reliable results, making it ideal for applications in drug development, quality control, and bioprocessing.

Gator Bio's BLI instruments offer unparalleled precision and efficiency for quantitation applications.

BLI empowers researchers to study molecular interactions with real-time, label-free kinetics analysis. By delivering precise association and dissociation rate constants, as well as binding affinities, BLI simplifies the characterization of biomolecular interactions. Its high sensitivity and straightforward workflows allow scientists to gain a deeper understanding of binding mechanisms, critical for therapeutic development, screening, and basic research.

Gator BLI is compatible with a wide range of biomolecules for kinetic investigations: antibodies, nanobodies, small molecules, membrane proteins, AAV, nucleic acids, and more. BLI is a mainstay for the label-free measurement of biomolecular interactions.

Knowing the epitope of an antibody is crucial to understanding its biology and therapeutic potential. Running epitope binning analysis earlier in the drug discovery pipeline can save time and increase efficiency. BLI simplifies the complex process of epitope binning with its high-throughput and real-time analysis capabilities. Researchers can characterize antibody binding profiles, differentiate overlapping or unique epitopes, and identify binding competition with ease. This powerful tool accelerates antibody discovery and development, offering clear and actionable insights into epitope diversity and target interactions.

Gator BLI can handle crude supernatants to allow epitope binning at the earliest drug discovery phase. Intellectual property rights can be known earlier to make sure you stand out among competitors.

From material to surface to results, our precoated, ready-to-use biosensors offer improved sensitivity, reduced nonspecific binding and a higher capacity to expand the user’s applications. Robust enough to take on serum and plasma, our biosensors can handle a vast array of applications and samples — both crude and purified — and can be regenerated and reused to lower the cost per assay and to increase the walk-away time of any assay.

Q = Quantitation; K = Kinetics; EP = Epitope Binning

Don't see what you need? We can work with you to create a custom biosensor for your application.

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